The relationship of childhood brain cancer survivors who were overweight or obese to be substantially better than the general populace of kids of the exact same age.

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Weight gain, becoming overweight or obese, and also hypothalamic-pituitary dysfunction (HPD) were discovered to it is in common among survivors that childhood brain cancer, according to the outcomes of a study released in the Journal that Clinical Oncology.1

Although previous researches have suggested that excessive weight is very prevalent amongst childhood brain cancer survivors, these cohorts may have actually overestimated or underestimated obesity or load gain because of inclusion and also exclusion criteria. The target of this study was to identify the ubiquity of weight gain and becoming overweight or obese and also the association with HPD in a cohort of noncraniopharyngioma and also nonpituitary childhood brain cancer survivors.

The retrospective study evaluated data indigenous 661 children diagnosed with noncraniopharyngioma and also nonpituitary mind cancers in between 2002 and 2012. The world Health organization (WHO) interpretations of underweight, overweight, and also obesity were used for infants aged 0 come 2 years; because that older children, the international cutoff points figured out by Cole et al to be used.2 Weight get was defined as an increase of at the very least 2.0 traditional deviation score (SDS) in human body mass index (BMI).1

Weight obtain or gift overweight or obese to be reported amongst 33.1% the the cohort during a mean follow-up of 7.3 years.

The ratio of childhood brain cancer survivors that were overweight or obese was substantially higher than the general populace of youngsters of the exact same age. In the 4-to-20 age group, 28.7% the childhood brain cancer survivors were overweight or obese contrasted with 13.2% the the general population.

Weight gain was significantly associated with factors including lower BMI SDS at diagnosis (odds proportion , 0.51; 95% CI, 0.40-0.66), whereas becoming overweight or obese to be significantly linked with a higher BMI SDS at diagnosis (OR, 2.00; 95% CI, 1.70-2.34).

Presence of central precocious puberty in ~ follow-up was likewise associated with weight obtain (OR, 4.06; 95% CI, 1.58-10.42) and becoming overweight or obese (OR, 3.12; 95% CI, 1.38-7.04). Various other risk determinants for becoming overweight or obese contained a diagnosis that low-grade glioma (OR, 1.68, 95% CI, 1.05-2.67) and diabetes insipidus in ~ follow-up (OR, 6.41; 95% CI, 1.35-30.41).

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A diagnosis that HPD was additionally common in the cohort, v 22.8% the childhood brain cancer survivors diagnosed with one or more HPD disorder in ~ follow-up. The the 74.3% that childhood brain cancer survivors that underwent endocrine testing, 30.8% were diagnosed with at least 1 HPD through a mean onset of diagnosis the 3 year after mind tumor diagnosis.

The authors concluded the these results show “a high prevalence of far-reaching weight gain, overweight, and obesity during follow-up.” They included that “these childhood brain cancer survivors need to receive endocrine surveillance and early support concerning weight control as they room at serious risk because that adverse metabolic health.”