1) Penicillin was considered a "miracle drug" for all of the complying with reasons EXCEPT

A) it was the very first antibiotic.

You are watching: In what way are semisynthetic penicillins and natural penicillins alike?

B) it does not impact eukaryotic cells.

C) it inhibits gram-positive cell wall synthesis.

D) it has actually selective toxicity.

E) it death bacteria.

2) A drug that inhibits mitosis, such as griseofulvin, would certainly be much more effective against

A) gram-positive bacteria.

B) gram-negative bacteria.

C) fungi.

D) wall-less bacteria.

E) mycobacteria.

3) many of the easily accessible antimicrobial agents are effective against

A) viruses.

B) bacteria.

C) fungi.

D) protozoa.

E) every one of the answers are correct.

4) Antimicrobial peptides (AMPs) generally work by

A) inhibiting protein synthesis.

B) disrupting the plasma membrane.

C) complementary basic pairing through DNA.

D) inhibiting cell-wall synthesis.

E) hydrolyzing peptidoglycan.

5) In what method are semisynthetic penicillins and also natural penicillins alike?

A) Both are vast spectrum.

B) Both space resistant come penicillinase.

C) Both space resistant to stomach acids.

D) Both space bactericidal.

E) Both are based upon β-lactam.

6) which of the complying with antibiotics is not bactericidal?

A) aminoglycosides

B) cephalosporins

C) polyenes

D) rifampins

E) penicillin

7) Which among the complying with does no belong through the others?

A) bacitracin

B) cephalosporin

C) monobactam

D) penicillin

E) streptomycin


The antibiotic tetracycline binds to the 30S subunit the the ribosome, as displayed by the dark black bar ~ above the right portion of the diagram in number 20.1. The impact is to

A) stop attachment of DNA.

B) prevent peptide link formation.

C) stop transcription.

D) protect against the ribosomes from moving along the mRNA.

E) interfere v the attachment of the tRNA to mRNA-ribosome complex.


The antibiotic chloramphenicol binds to the 50S subunit the the ribosome, as shown in number 20.2. The effect is to

A) protect against mRNA-ribosome binding in eukaryotes.

B) stop peptide bond formation in prokaryotes.

C) avoid polypeptide elongation in eukaryotes.

D) prevent transcription in prokaryotes.

E) stop ribosome development in bacteria.

10) which of the complying with antimicrobial agents has the fewest side effects?

A) streptomycin

B) tetracycline

C) penicillin

D) erythromycin

E) chloramphenicol

11) i m sorry of the following drugs does no act by vain inhibition?

A) ethambutol

B) isoniazid

C) streptomycin

D) sulfonamide

E) trimethoprim

12) which of the adhering to methods of action would be bacteriostatic?

A) competitive inhibition v folic mountain synthesis

B) inhibition that protein synthesis

C) injury come plasma membrane

D) inhibition the cell wall synthesis

E) compete inhibition through DNA gyrase

13) i m sorry of the adhering to antibiotics is recommended for use versus gram-negative bacteria?

A) polyenes

B) bacitracin

C) cephalosporin

D) penicillin

E) polymyxin

14) i beg your pardon of the adhering to antimicrobial agents is recommended for use versus fungal infections?

A) amphotericin B

B) bacitracin

C) cephalosporin

D) penicillin

E) polymyxin


15) 5) In Table 20.1, as shown by the data shown, the minimal bactericidal concentration of antibiotic X is

A) 2 μg/ml.

B) 10 μg/ml.

C) 15 μg/ml.

D) 25 μg/ml.

E) The answer can not be determined based on the info provided.


16) In Table 20.1, the minimal inhibitory concentration that antibiotic X is

A) 2 μg/ml.

B) 10 μg/ml.

C) 15 μg/ml.

D) 25 μg/ml.

E) The answer can not be determined based upon the details provided.

17) an ext than fifty percent of ours antibiotics are

A) created by fungi.

B) created by bacteria.

C) synthesized in laboratories.

D) developed by Fleming.

E) created by eukaryotic bio organisms.

18) to date, most of our natural antibiotics have actually been found to be produced by members that what genus?

A) Streptomyces

B) Bacillus

C) Penicillium

D) Paenibacillus

E) Cephalosporium

19) which of the following is mismatched?

A) Ehrlich — "magic bullet" theory

B) Fleming — initial identification of penicillin"s impact on gram-positive microbial growth

C) Florey and Chain — identification of Penicillium together the producer the penicillin

D) Kirby and also Bauer — disc-diffusion method

E) none of these is mismatched.

20) i beg your pardon compound would be the most helpful to act candidiasis?

A) uracil

B) thymine

C) flucytosine

D) guanine

E) penicillin

21) which of the adhering to antibiotics are used to law fungal infections?






A) 1, 2, and 3

B) 3 and 4

C) 3, 4, and also 5

D) 4 and 5

E) all of these antibiotics are offered to act fungal infections.

22) i beg your pardon of the following antibiotics does not interfere with cell wall synthesis?

A) cephalosporins

B) macrolides

C) natural penicillins

D) semisynthetic penicillins

E) vancomycin

23) The antimicrobial drugs with the broadest spectrum of task are

A) aminoglycosides.

B) chloramphenicol.

C) penicillin G.

D) macrolides.

E) tetracyclines.

24) which of the adhering to statements is FALSE?

A) Fluoroquinolone inhibits DNA synthesis.

B) Acyclovir inhibits DNA synthesis.

C) Amantadine inhibits the relax of viral nucleic acid.

D) Interferon inhibits glycolysis.

E) Azoles inhibit plasma membrane synthesis.

25) Protozoan and helminthic illness are daunting to treat because

A) your cells room structurally and also functionally similar to human being cells.

B) lock replicate inside human being cells.

C) they perform not have actually ribosomes.

D) they do not reproduce.

E) castle have an ext genes 보다 bacteria.

26) which of the following organisms would MOST likely be sensitive to organic penicillin?

A) helminths

B) Streptococcus pyogenes

C) penicillinase-producing Neisseria gonorrhoeae

D) Penicillium

E) Mycoplasma

27) i m sorry of the complying with statements about drug resistance is FALSE?

A) It may be lugged on a plasmid.

B) It may be moved from one bacterium to another during conjugation.

C) It might be as result of enzymes that degrade some antibiotics.

D) the is discovered only in gram-negative bacteria.

E) It might be as result of increased absorb of a drug.

28) which of the adhering to does not constitute an benefit of using 2 antibiotics together?

A) It deserve to prevent drug resistance.

B) that lessens the toxicity of individual drugs.

C) two are always twice as reliable as one.

D) It permits treatment to be noted prior come diagnosis.

E) all of these are advantages of using 2 antibiotics together.

29) medicine resistance occurs

A) because bacteria space normal microbiota.

B) as soon as antibiotics are used indiscriminately.

C) against antibiotics and also not against synthetic chemotherapeutic agents.

D) once antibiotics space taken after ~ the symptom disappear.

E) every one of the answers room correct.


30) In Table 20.2, the most reliable antibiotic experiment was

A) A.

B) B.

C) C.

D) D.

E) The answer cannot be determined based upon the info provided.


31) In Table 20.2, the antibiotic that showed bactericidal activity was

A) A.

B) B.

C) C.

D) D.

E) The answer cannot be determined based upon the information provided.


32) In Table 20.2, i beg your pardon antibiotic would certainly be most helpful for dealing with a Salmonella infection?

A) A

B) B

C) C

D) D

E) The answer can not be determined based on the information provided.

33) i beg your pardon of the adhering to would it is in selective against the tubercle bacillus?

A) bacitracin — inhibits peptidoglycan synthesis

B) ethambutol — inhibits mycolic acid synthesis

C) streptogramin — inhibits protein synthesis

D) streptomycin — inhibits protein synthesis

E) vancomycin — inhibits peptidoglycan synthesis

34) In the presence of penicillin, a cell dies because

A) it lacks a cabinet wall.

B) it plasmolyzes.

C) it experience lysis.

D) the lacks a cabinet membrane.

E) its materials leak out.

35) Lamisil is one allylamine offered to act dermatomycoses. Lamisil"s technique of activity is similar to the of

A) polymyxin B.

B) azole antibiotics.

C) echinocandins.

D) griseofulvin.

E) bacitracin.

36) Niclosamide stays clear of ATP generation in mitochondria. Friend would suppose this medicine to be efficient against

A) gram-negative bacteria.

B) gram-positive bacteria.

C) helminths.

D) Mycobacterium tuberculosis.

E) viruses.


The data in Table 20.3 present that these bacteria

A) are pathogenic.

B) arisen resistance to antibiotics.

C) were killed by 0.125 μg/ml the antibiotic X.

D) were killed by 0.5 μg/ml that antibiotic X.

E) to be resistant come 1.0 μg/ml in ~ the begin of the experiment.

38) i beg your pardon of the adhering to statements around drugs the competitively inhibit DNA polymerase or RNA polymerase is FALSE?

A) They have the right to potentially reason mutations.

B) They space used against viral infections.

C) lock can affect host cell DNA synthesis.

D) They cause cellular plasmolysis.

E) lock interfere through protein synthesis.


The substrate for transpeptidase provided to synthesize peptidoglycan is shown in figure 20.3. I m sorry of the drugs displayed would inhibit peptidoglycan synthesis?

A) a B) b C) c D) d E) e

The structures of the influenza medicine Tamiflu and also sialic acid, the substrate because that influenza virus"s neuramidase, are presented in number 20.4. What is the an approach of activity of Tamiflu?

A) inhibits cell wall surface synthesis

B) inhibits plasma membrane synthesis

C) inhibits synthesis of neuramidase

D) vain inhibition

E) stays clear of synthesis the virus spikes

41) i beg your pardon of the following does NOT influence eukaryotic cells?

A) antiprotozoan drugs

B) antihelminthic drugs

C) antifungal drugs

D) nucleotide analogs

E) semisynthetic penicillins

42) Mebendazole is offered to law cestode infections. That interferes v microtubule formation; therefore, it would NOT affect

A) bacteria.

B) fungi.

C) helminths.

D) human being cells.

E) protozoa.

43) i beg your pardon of the following antibiotics causes misreading the mRNA?

A) aminoglycoside — transforms shape of 30S units

B) chloramphenicol — inhibits peptide bonds in ~ 50S subunit

C) oxazolidinone — stays clear of formation the 70S ribosome

D) streptogamin — avoids release the peptide native 70S ribosome

E) tetracyclines — bind with 30S subunit

44) The antibiotic actinomycin D binds between adjacent G-C pairs, thus interfering with

A) transcription.

B) translation.

C) to move respiration.

D) plasma membrane function.

E) peptide shortcut formation.

45) usage of antibiotics in animal feed leads to antibiotic-resistant bacteria because

A) bacteria native other animals replace those eliminated by the antibiotics.

B) the few surviving bacteria the are influenced by the antibiotics build immunity to the antibiotics, i m sorry they happen on to your progeny.

C) the antibiotics cause brand-new mutations to happen in the enduring bacteria, which outcomes in resistance to antibiotics.

D) the antibiotics kill prone bacteria, but the few that are normally resistant live and also reproduce, and also their progeny repopulate the hold animal.

E) the antibiotics persist in soil and also water.

Answer: D


1) one antibiotic that attacks the LPS layer would certainly be meant to have actually a small spectrum that activity.

Answer: TRUE


2) PABA serves as the vain inhibitor in the action of sulfanilamides.

Answer: FALSE


3) Undergrowth of fungi after antibiotic use is frequently referred to together a superinfection.

Answer: FALSE


4) due to its target, rifamycins deserve to be reliable over a broad spectrum.

Answer: TRUE


5) Both trimethoprim and also sulfamethoxazole inhibit reactions along the very same metabolic pathway.

Answer: TRUE


6) Penicillin and streptomycin are typically used in synergism since they screen the same setting of action.

Answer: FALSE


7) only microbes produce antimicrobial peptides.

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Answer: FALSE


8) Community-acquired MRSA is typically much more virulent than health and wellness care-associated MRSA.